LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration
نویسندگان
چکیده
منابع مشابه
Predictors of Thyroid Gland Invasion in Laryngeal Squamous Cell Carcinoma
Introduction: Laryngeal squamous cell carcinoma (SCC) can invade the thyroid gland leading to unnecessary thyroidectomies with subsequent hypothyroidism and hyperparathyroidism. Thus, clinicopathological variables should be defined in order to predict thyroid gland invasion preoperatively. Materials and Methods: We performed a retrospective analysis of 1,465 patients with laryngeal SCC referr...
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Muc-1 is a member of the carbohydrate-binding protein family that contributes to neoplastic transformation, tumor survival, angiogenesis, and metastasis. The aim of this study is to investigate the role of muc-1 in human oral squamous cell carcinoma progression. In this study, we tested our hypothesis that muc-1 regulate oral squamous cell carcinoma cells (SCC-9) malignant biological behaviors,...
متن کاملDJ-1 Is Upregulated in Oral Squamous Cell Carcinoma and Promotes Oral Cancer Cell Proliferation and Invasion
BACKGROUND The development of oral squamous cell carcinoma (OSCC) is a multistep process that involves in both genetic alterations and epigenetic modifications. DJ-1, a negative regulator of tumor suppressor PTEN, functions as an oncogene in many types of cancers. However, its role in OSCC is poorly known. METHODS Immunohistochemical staining and Western blotting were performed to evaluate th...
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Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was pe...
متن کاملHigh interstitial fluid pressure promotes tumor cell proliferation and invasion in oral squamous cell carcinoma.
It has been shown that interstitial fluid pressure (IFP) is elevated in many solid tumors. The elevated IFP in tumors is responsible, at least in part, for the poor blood supply, inadequate delivery of therapeutic agents to solid tumors and poor treatment response in patients. The present study was carried out to examine alterations in malignant phenotypes in oral squamous cell carcinoma cells ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2016
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2016.167